Lithiation–borylation methodology in the total synthesis of natural products

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...

Lessons from total synthesis of hybrid natural products.

There are a vast number of interesting and useful compounds that are readily found in nature. Mother Nature has acquired ingenious ways of generating molecular diversity in living cells responsible for regulation of various biochemical events. This has inspired research into the synthesis of biologically active compounds for use as antibiotics or in cancer therapy, for example. This account pro...

Total Synthesis of Bioactive Natural Products - A Personal Perspective

Total synthesis of complex molecular architectures has long been recognized as the most powerful form of training for synthetic organic chemists. This historical discipline has a rich and glorious tradition in both teaching and research, and is an indispensible component in any chemistry department and scientific institutions. Scientifically, in addition to the synthetic challenges associated w...

Structural revisions of natural products by total synthesis.

Total synthesis and development of bioactive natural products

The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key...